发明名称 |
SYNTHESIS AND METHODS OF USE OF TETRAHYDROINDOLONE ANALOGUES AND DERIVATIVES |
摘要 |
A tetrahydroindolone derivative or analogue comprises a 9-atom bicyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y1)-D, where Y1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption or blood-brain barrier penetration of the derivative or analogue. The moiety A has a six-membered ring fused to a five-membered ring. The moiety A can be have one, two, or three nitrogen atoms in the five membered ring. The moiety A can be a tetrahydroindolone moiety. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity. In general, a bifunctional conjugate according to the present invention has the schematic structure (1) where A is a 9-atomic bicycle moiety in which the five-membered ring has 1 to 3 nitrogen atoms, the bicyclic moiety having the structure (2). |
申请公布号 |
WO02085856(A1) |
申请公布日期 |
2002.10.31 |
申请号 |
WO2002US11142 |
申请日期 |
2002.04.08 |
申请人 |
NEOTHERAPEUTICS, INC.;FICK, DAVID, B.;FOREMAN, MARK, M.;GLASKY, ALVIN, J. |
发明人 |
FICK, DAVID, B.;FOREMAN, MARK, M.;GLASKY, ALVIN, J. |
分类号 |
A61P25/28;C07D209/88 |
主分类号 |
A61P25/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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