BENZIMIDAZOLONE DERIVATIVES

摘要

Benzimidazolone derivatives typified by compounds represented by the following general formula [I] and so on: wherein R<1> and R<2> represent each hydrogen, etc.; R<3a>, R<3b>, R<4> and R<5> represent each hydrogen, alkyl, etc.; R<6> represents aryl, heteroaryl, etc.; the ring A represents a 5- to 8-membered aliphatic heterocycle having a nitrogen atom; and Z represents carbonyl or sulfonyl. Because of having an antagonistic effect to muscarinic acetylcholine receptor, the above benzimidazolone derivatives are useful as remedies and/or preventives for, e.g., Parkinson's disease, drug-induced Parkinsonism, dystonia, akinesia, pancreatitis, bilestone/cholecystitis, biliary mobility function error, achalasia, pain, itch, choline urticaria, irritable bowel syndrome, vomiting, vomiturition, stagger, Meniere's disease, rolling diseases such as space sickness, sea sickness and car sickness and urinary errors.