METHODS AND COMPOSITIONS FOR THE MODULATION OF BIOFILM FORMATION
摘要
The present invention relates to methods for the modulation of biofilm formation and antibiotic resistance. Specifically, the present invention identifies the differential expression of biofilm-associated genes in biofilms, relative to their expression in non-biofilm producing bacterial cells. The present invention also identifies the differential expression of biofilm-associated genes in biofilms treated with antibiotic, relative to their expression in untreated biofilms. The present invention describes methods for the diagnostic evaluation of biofilm formation. The invention also provides methods for identifying a compound capable of modulating biofilm formation and antibiotic resistance. The present invention also provides methods for the identification and therapeutic use of compound as treatments of biofilm-associated diseases or disorders.
申请公布号
WO02085295(A2)
申请公布日期
2002.10.31
申请号
WO2002US12532
申请日期
2002.04.19
申请人
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;WHITELEY, MARVIN;BANGERA, M., GITA;LORY, STEPHEN;GREENBERG, E., PETER;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人
WHITELEY, MARVIN;BANGERA, M., GITA;LORY, STEPHEN;GREENBERG, E., PETER