发明名称 |
ANTIMICROBIAL POLYMERIC SURFACES |
摘要 |
Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99 % of deposited Gram-positive and Gram- negative bacteria, whether deposited through air or water.
|
申请公布号 |
CA2445389(A1) |
申请公布日期 |
2002.10.31 |
申请号 |
CA20022445389 |
申请日期 |
2002.04.16 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;TRUSTEES OF TUFTS COLLEGE |
发明人 |
LEWIS, KIM;KLIBANOV, ALEXANDER M.;LIAO, CHUN-JEN;TILLER, JOERG C. |
分类号 |
A61L17/00;A01N43/40;A01N61/00;A61L2/16;A61L2/232;A61L15/58;A61L27/00;A61L31/00;A61P31/04;B05D3/10;B05D5/00;B05D7/24;B32B27/04;B32B27/08;B32B27/30;B32B27/32;B32B27/34;B32B27/36;C08F26/06;C08F283/00;C08F283/02;C08F283/04;C08F292/00;C08J5/12;C08J7/04;C08J7/06;C08L39/08;C08L67/03;C08L77/06;(IPC1-7):A01N43/40;A61K7/40 |
主分类号 |
A61L17/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|