发明名称 1,4-dihydropyridine compounds as bradykinin antagonists
摘要 The present invention relates to compounds of the formula wherein each A is independently halo; Y is -(CH2)m-, -C(O)- or -S(O)-; R1 and R2 are independently C1-4 alkyl; R3 is substituted azacycloalkyl etc.; R4 is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R5 is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.
申请公布号 US2002161006(A1) 申请公布日期 2002.10.31
申请号 US20010903157 申请日期 2001.07.11
申请人 KAWAMURA MITSUHIRO;KAWAI MAKOTO;SHISHIDO YUJI;KATO TOMOKI;KATSU YASUHIRO;IKEDA TAKAFUMI;MURASE NORIAKI 发明人 KAWAMURA MITSUHIRO;KAWAI MAKOTO;SHISHIDO YUJI;KATO TOMOKI;KATSU YASUHIRO;IKEDA TAKAFUMI;MURASE NORIAKI
分类号 C07D211/90;A61K31/46;A61K31/495;A61K31/496;A61K31/497;A61K31/5377;A61P1/16;A61P1/18;A61P3/10;A61P3/12;A61P7/10;A61P9/00;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P13/10;A61P13/12;A61P17/02;A61P17/04;A61P19/02;A61P19/08;A61P25/00;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/28;A61P27/00;A61P27/06;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P35/04;A61P37/08;A61P43/00;C07D401/12;C07D451/04;(IPC1-7):A61K31/537;C07D413/14;C0743/14 主分类号 C07D211/90
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