摘要 |
Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the <i>in situ</i> formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material. |
申请人 |
CRYOLIFE, INC.;YUKSEL, K., UMIT;BIRD, ANA, T.;BLACK, KIRBY, S. |
发明人 |
YUKSEL, K., UMIT;BIRD, ANA, T.;BLACK, KIRBY, S. |