USE OF PPAR-ALPHA-GAMMA LIGANDS OR AGONISTS TO PREVENT THE RUPTURE OF ATHEROSCLEROTIC PLAQUES

摘要

The invention encompasses a method for preventing the rupture of atherosclerotic plaques in a mammalian patientin need of such prevention comprising administering to said patient a compound that is capable of simultaneously binding or binding and activating PPAR alpha and PPAR gamma or concomitantly administering a selective PPAR alpha agent with a selective PPAR gamma agent in an amount that is effective to prevent the rupture of atherosclerotic plaques. The invention also encompasses a method for increasing atherosclerotic plaque stability in a mammalian patient in need thereof comprising administering to said patient a compound that is capable of simultaneously binding or binding and activating PPAR alpha and PPAR gamma or concomitantly administering a selective PPAR alpha agent with a selective PPAR gamma agent in an amount that is effective to increase plaque stability.