| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing an optically active 3-cyano-2- methylpropanol derivative useful as an intermediate for a medicine, an agrochemical or the like from an inexpensive raw material by a simple operation. SOLUTION: An optically active 3-hydroxy-2-methylpropanoic acid derivative is halogenated, and the product is optionally subjected to solvolysis. The resultant product is reduced to provide an optically active 3-halo-2-methylpropanol derivative, and the 3-halo-2-methylpropanol derivative, optionally after protecting the hydroxy group, is reacted with a metal cyanide compound to provide the objective optically active 3-cyano-2-methylpropanol derivative.
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