| 摘要 |
PROBLEM TO BE SOLVED: To provide an excellent prophylactic and therapeutic agent for tachykinin-intervening diseases. SOLUTION: The objective medicine contains as an active ingredient, a compound represented by the following general formula (I) (R<1> : an alkyl; R<2> : a nitrogen-containing 5-membered heteroaryl which may be substituted, a nitrogencontaining 5-membered heterocyclyl which may be substituted; R<3> : an aryl which may be substituted, a heteroaryl which may be substituted; A: CO, SO2 ; E: CH2 , O, S; G: a cycloalkane ring which may be substituted, a cycloalkene ring which may be substituted; a saturated heterocyclic ring which may be substituted; Ar: an aryl ring which may be substituted, a heteroaryl ring which may be substituted; m: 1, 2; n: 2-4), a pharmacologically acceptable salt thereof, an ester thereof or the other derivatives.
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