A PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES

摘要

An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula (II) and enzymatically converting a compound of formula (II) to form a 3-thiolated-7-ACA of the formula (III) wherein R is a heterocyclic group comprising at least one nitrogen atom and R1 And R2 are both hydrogen atoms or one of them is a hydrogen atom and the other is an acyl donor.