| 摘要 |
<p>The invention concerns a non-recombinant cell line expressing predominantly PDE4 subtype, more preferably PDE4B. The inve ntion also concerns a non-recombinant cell line capable, under appropriate conditions, of exhibiting an upregulated expression of a single target protein, preferably a PDE4 subtype, more preferably PDE4B. The invention also concerns methods for the screening of a candidate molecule that modulates the expression of the activity of human phosphodiesterase 4B. The candidate molecules selected by the screening methods of the invention are potentially useful as therapeutic molecules for diseases caused or regulated by cyclic nucleotide-modulated transduction mechanisms, such as airway disorders like asthma.</p> |
