发明名称 |
MELANOCORTIN RECEPTOR LIGANDS |
摘要 |
Disclosed are MC-3/MC-4 receptor ligands, the ligands having the formula (I) wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic rings; b) aromatic carbocyclic rings; c) non-aromatic heterocyclic rings; d) aromatic heterocyclic rings; wherein said rings comprises from 5 to 8 atoms; and W is a unit which preferable comprises D-1-fluorophenyalanine, Y comprises a heteroatom, and Z comprises an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the invention as well as methods of treating diseases mediated through MC-3/MC-4 receptors. |
申请公布号 |
WO02085925(A2) |
申请公布日期 |
2002.10.31 |
申请号 |
WO2002US13340 |
申请日期 |
2002.04.24 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
MAZUR, ADAM, WIESLAW;TIAN, XINRONG;HU, XIUFENG, ERIC;EBETINO, FRANK, HALLOCK |
分类号 |
C07D241/04;A61K31/40;A61K31/4453;A61K31/495;A61K31/496;A61P3/06;A61P3/10;A61P5/00;A61P7/00;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P15/00;A61P15/08;A61P15/10;A61P21/04;A61P29/00;A61P31/04;A61P35/00;C07D207/12;C07D211/46;C07D241/06;C07D241/08;C07D401/12;C07D403/06 |
主分类号 |
C07D241/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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