| 摘要 |
1. A pharmaceutical composition containing as active agent at least one compound selected from the group consisting of: compound of formula (I) and compound of formula (II) and pharmaceutically acceptable acid in an amount, improving stability thereof. 2. The composition of Claim 1, wherein said pharmaceutically acceptable acid is selected from the group consisting of citric acid, glutamic acid, succinic acid, ethanesulfonic acid, acetic acid, tartric acid, ascorbic acid, methanesulfonic acid, fumaric acid, adipic acid, malic acid and mixtures thereof. 3. The composition of Claim 2, characterized in that it is solid dosage form wherein the active particles are granulated in the presence of a granulating agent to form granulated active solid particles. 4. The composition of Claim 2, characterized in that it is solid particles suspension of at least one of compounds of formula I and formula II in liquid. 5. The composition of Claim 4, wherein the liquid is water. 6. The composition of Claim 4, wherein the pH of said suspension is between 2 and 6. 7. The composition of Claim 4, wherein the pH of said suspension is between 3 and 5. 8. The composition of Claim 2, which is a paste, said paste comprising solid particles of at least one compounds of formula I and formula II, wetting agent and a thickener. |
