发明名称 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof |
摘要 |
A protein belonging to the TNF superfamily called TRANCE involved in signal transduction, along with nucleic acids comprising DNA sequences and degenerate variants thereof which encode TRANCE are disclosed. Modulators which are TRANCE agonists and TRANCE antagonists are also disclosed, and can be used in pharmaceutical compositions and methods disclosed herein to modulate the active life of mature dendritic cells, T cell activation, and immune response in mammal.
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申请公布号 |
US2002159970(A1) |
申请公布日期 |
2002.10.31 |
申请号 |
US20010017910 |
申请日期 |
2001.12.14 |
申请人 |
CHOI YONGWON;WONG BRIAN;JOSIEN REGIS;STEINMAN RALPH |
发明人 |
CHOI YONGWON;WONG BRIAN;JOSIEN REGIS;STEINMAN RALPH |
分类号 |
A61K38/00;A61K38/19;C07K14/525;C12Q1/68;(IPC1-7):A61K38/19;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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