发明名称 |
ACTIVE SITE INACTIVATORS |
摘要 |
A method for identifying active site inhibitors of scission enzyme that cleaves the backbones or side groups of peptides, and for using the resultan t inactivators to inhibit the target scission enzyme. Kinetic assays are employed to identify peptide substrates that tightly bind to the active site of the target protease but that are not easily cleaved. These noncleavable b ut tightly binding substrates are optionally structurally modified to yield inhibitory compounds with optimized properties. Additionally these substrate s exhibit apparent specificity for a transition state or ground state configuration of the protease.
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申请公布号 |
CA2444209(A1) |
申请公布日期 |
2002.10.31 |
申请号 |
CA20022444209 |
申请日期 |
2002.04.22 |
申请人 |
THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
BAIG, SALMAN |
分类号 |
G01N33/53;C12N9/50;C12N9/99;G01N24/08;G01N33/573;(IPC1-7):C12N9/50;C12Q1/34;C12Q1/37;C12Q1/42;C12Q1/44 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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