发明名称 |
Cardiotrophin-1 defective mouse |
摘要 |
The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
|
申请公布号 |
US6472585(B1) |
申请公布日期 |
2002.10.29 |
申请号 |
US20000648183 |
申请日期 |
2000.08.25 |
申请人 |
GENENTECH, INC. |
发明人 |
BOTSTEIN DAVID;GODDARD AUDREY;LAWRENCE DAVID A.;PENNICA DIANE;ROY MARGARET ANN;WOOD WILLIAM I. |
分类号 |
A61K38/00;C07K14/47;C07K14/52;C07K16/18;C07K16/24;(IPC1-7):A01K67/027;C12N15/00;G01N33/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|