发明名称 Method for the production and use of a cream containing vitamin-A
摘要 A method for the production of a vitamin-A containing cream comprising the following steps:a) a first mixture-consisting of a number of water-soluble substances such as glycerine and extracts of plants-is mixed together during heating and comminution until the mixture has a temperature of about some 80° C., preferably 83° C.,b) a second mixture consisting of a number of oil-soluble substances, including emulsifiers, and squalane and vegetable oils such as avocado oil are mixed together during heating until the mixture has a temperature of about some 80° C., preferably 83° C.,c) said first mixture is then gradually added to said second mixture during high-shear-mixing with decreasing number of revolutions-from about 5000 rpm to about 3300 rpm-until the temperature of the mixture slowly has decreased to about some 50° C., preferably 51° C.,d) said last mixture is then added to a third mixture containing of alpha-tocopherol, tocopherol acetate, retinyl palmitate and retinyl acetate preferably in the following mutual relation 10:50:61:58-determined in accordance with the used mixture of vitamines,e) the final mixture is then successively homogenized at a pressure of about 1000 bar and then kept at constants temperature of some 50° C., until the whole mixture is homogenized, whereafter the mixture is high-shear-mixed with decreasing number of revolution until the temperature is about some 40° C., preferable 45° C.,f) finally, the viscosity of the cream is adjusted by stirring.
申请公布号 US6471954(B2) 申请公布日期 2002.10.29
申请号 US20010767836 申请日期 2001.01.24
申请人 CORTEX TECHNOLOGY APS 发明人 CHRISTENSEN FLEMMING KJæRGAARD
分类号 A61K8/37;A61K8/67;A61K8/92;A61K9/06;A61K31/01;A61K31/07;A61K31/355;A61P17/00;A61Q19/00;A61Q19/08;(IPC1-7):A61K31/74;A61K7/42;C07D311/76 主分类号 A61K8/37
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