发明名称 |
METHOD FOR THE PREPARATION OF CITALOPRAM |
摘要 |
A method for the preparation of citalopram is described comprising reduction of the oxo group of a compound of formula (IV), wherein R1 is CN, C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, ring closure of the resulting hydroxy compound thereby obtaining the corresponding 1-(4-fluorophenyl)-1,3- dihydroisobenzofuran, then if R1 is cyano using it directly in the next step and if R1 is C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, conversion of the compound to the corresponding compound wherein R1 is cyano; and alkylati on of the resulting 5-cyano compound with 3-dimethyl-aminopropylhalogenid in basic conditions thereby obtaining citalopram.
|
申请公布号 |
CA2291068(C) |
申请公布日期 |
2002.10.29 |
申请号 |
CA19972291068 |
申请日期 |
1997.11.10 |
申请人 |
H. LUNDBECK A/S |
发明人 |
PETERSEN, HANS;BOGESO, KLAUS PETER;BECH SOMMER, MICHAEL |
分类号 |
A61K31/34;A61K31/343;A61P25/24;C07B61/00;C07C51/347;C07C65/105;C07C69/76;C07C231/12;C07C235/42;C07C253/30;C07C255/53;C07D307/87;C07D307/88;(IPC1-7):C07D307/87 |
主分类号 |
A61K31/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|