| 摘要 |
A compound selected from Formula (I) hereinbelow:or a pharmaceutically acceptable salt thereof, whereinm is an integer from 0 to 2; n is an integer from 1 to 3;X is selected from the group consisting of CN, NO2, Cl, F, and H;Y is selected from the group consisting of Cl, F, Br, I and H; andQ and Z are, independently, selected from the group consisting of H, R1, SO2R1', R1C(O)OR1'', SO2NR1'R1'', C(O)NR1'R1'', NR1'SO2R''1, wherein R1, R1' and R1'' are independently selected from the group consisting of hydrogen, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C2-5 alkynyl, heterocycloalkyl, aryl and aryl C1-4 alkyl; or R1' and R1'' together form a 3 to 7 membered optionally substituted heterocyclic ring; wherein any substituents are selected from the group consisting of CN, aryl, CO2R, CO2NHR, OH, OR, NH2, halo, CF3, OCF3 and NO2; wherein R represents H, C1-4 alkyl, and C3-6 cycloalkyl; and A is phenyl or naphthyl, unsubstituted or substituted with any substituents being selected from the group consisting of OH, halo, CO2R1, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, OSO2R1, CN, NO2, OCF3, CF3, and CH2CF3, (CH2)nCO2H, (CH2)nCO2R1, and O-(CH2)n CO2R1, wherein n is an integer from 0 to 3 0-3 and R1 represents C1-4 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl, heteroaryl or fused heteroaryl (wherein the hetero-ring can contain N, O or S and can be aromatic, dihydro or tetrahydro) unsubstituted or substituted with any substituents being selected from the group consisting of OH, OCH3, CH(CH3)2</HIL |
