Spray coated powder composition formed from seed particles between 10-100 micrometres coated with an aqueous pharmaceutical composition

摘要

Described are spray-coated pharmaceutical powder compositions for transdermal administration using a needless syringe comprising seed particles coated with a pharmaceutical composition. The coated seed particles have an average size of between 10 and 100 micrometres and an envelope density ranging from 0.1 to 25g/cm2. A method for preparing the spray-coated powder is disclosed. The method comprising the steps of: (a) suspending the seed particles in a reaction chamber using a heated airflow; (b) atomising an aqueous pharmaceutical composition into a spray and introducing the spray into the reaction chamber; (c) allowing the spray to spread over the surface of the suspended seed particles so they are coated with a film; and (d) drying the coated seed particles.