New 1-(heterocyclyl-alkyl)-4-(phenyl or pyridyl)-tetrahydropyridines, are tumor necrosis factor-alpha synthesis inhibitors useful for treating autoimmune or inflammatory diseases or pain

摘要

1-(Benzoheterocyclyl-alkyl)-4-(phenyl or pyridyl)-1,2,3,6-tetrahydropyridine derivatives (I) are new. Tetrahydropyridine derivatives of formula (I) and their N-oxides, salts and solvates are new. X = CH or N; R1 = H, halo or CF3; R2, R3 = H or Me; m, n = 0 or 1; A = nitrogen-containing benzo-group of formula (a) - (i); R4 - R6 = H or 1-4C alkyl; R7, R8 = H, halo, 1-4C alkyl or 1-4C alkoxy; dotted line = optional bond; provided that if X = CH, then group A (a) is not indol-4-yl. Independent claims are included for: (1) the preparation of (I); and (2) the use of compounds (I) without the proviso (or their N-oxides, salts or solvates) in the preparation of medicaments for use as analgesics and/or treatment of diseases associatd with immunological and inflammatory disorders.