Genetically modified Salmonella sp having a modified msbB gene useful for treating tumours

摘要

A mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumours. The Salmonella sp. contains a genetically modified msbB gene as well as a genetic modification in a biosynthetic pathway gene such as the purI gene. Also described are the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumours.