| 发明名称 |
MODIFIED HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR AND PROCESS FOR PRODUCING SAME |
| 摘要 |
A modified human granulocyte-colony stimulating factor(hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF(SEQ ID NO: 2) with other amino acid |
| 申请公布号 |
EP1194575(A4) |
申请公布日期 |
2002.10.24 |
| 申请号 |
EP20000942494 |
申请日期 |
2000.07.07 |
| 申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
KWON, SE CHANG;JUNG, SUNG YOUB;BAE, SUNG MIN;LEE, GWAN SUN |
| 分类号 |
C12N15/09;A61K38/00;A61P35/02;C07K14/535;C12N1/21;C12N15/12;C12N15/27;C12N15/62;C12N15/70;C12P21/00;C12P21/02;C12R1/19 |
主分类号 |
C12N15/09 |
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