摘要 |
There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert -butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert -butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert -butyl 2-{7-[(2 S )-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arrhythmias.
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申请人 |
ASTRAZENECA AB;BARNWELL, NEIL;BJOERE, ANNIKA;CHEEMA, LAL;CLADINGBOEL, DAVID;HERRING, ADAM;LOEVQVIST, KARIN |
发明人 |
BARNWELL, NEIL;BJOERE, ANNIKA;CHEEMA, LAL;CLADINGBOEL, DAVID;HERRING, ADAM;LOEVQVIST, KARIN |