PHARMACEUTICAL FORMULATIONS CONTAINING ANTI-INFLAMMATORY ACTIVE INGREDIENTS AND THE USE OF SAID FORMULATIONS

摘要

The invention relates to compositions in the form of microemulsion preconcentrates containing: (a) a mixture consisting of a middle-chained triglyceride and an omega 9 fatty acid and/or an omega 6 fatty acid; (b) a surface-active component containing a polyoxyethylene-type surface-active agent; (c) a therapeutic active ingredient which is hardly soluble in water but soluble in component (a) and/or (b) from the category of non-steroidal anti-inflammatory drugs (NSAIDS). Microemulsions are formed when said microemulsions preconcentrates come into contact with water or an aqueous medium, wherein the oil-in-water type microemulsions have an average particl e size of less than 150 nm, preferably less than 100 nm. The microemulsion preconcentrates and microemulsions according to the invention are suitable f or oral and topical administration of non-steroidal anti-inflammatory drugs.