Saturated and unsaturated abietane derivatives, derived conjugates and uses in a diagnostic composition, a reagent and a device

摘要

The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among -COOR5, -CONR1R2, -COONR3R4, -COR6, -CON, -COOR5, -CHOHR7, -SR8, -OR8, -CN, -CNO, -CNS, -NCO, -NCS and -R1R2CR9; wherein R1, R2, R3 and R4 represent a hydrogen atom, a C1-C10 alkyl, a C6-C20 aryl optionally substituted, a C7-C10 alkene, a C1-C10 alkyne, or an aminoacyl or peptidyl optionally substituted; or R1 and R2 or R3 and R4 together form a cycle or a heterocycle; R5 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R6 represents a hydrogen, a halogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R7 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; R8 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; and R9 is selected among -CN, -CNO, -CNS, -NCO and -NCS. The invention also concerns a derived conjugate