SCREENING ASSAY FOR AGENTS MODULATING ACTIVITY OF THE ABCA1 PROTEIN

摘要

High throughput screening assays for agents capable of modulating lipid metabolism are disclosed. Such agents are detected by their ability to modulate the activity of proteins interacting with, and modulating the activity of, the protein expressed by the ABCA1 (called CERP - or cholesterol efflux regulating protein). Methods of treating disorders of lipid metabolism, especially those involving elevated levels of phospholipid or cholesterol, are also described.