发明名称 |
INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES |
摘要 |
The present invention provides compounds of formula (I): or a pharmaceutical ly acceptable derivative thereof, wherein A, B, Ra, R1, R2, R3 and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli; Lck an d Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprisi ng the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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申请公布号 |
CA2443487(A1) |
申请公布日期 |
2002.10.24 |
申请号 |
CA20022443487 |
申请日期 |
2002.04.10 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CAO, JINGRONG;GREEN, JEREMY;LEDEBOER, MARK;WANG, JIAN;HARRINGTON, EDMUND;MOON, YOUNG-CHOON;GAO, HUAI |
分类号 |
C12N15/09;A61K31/427;A61K31/506;A61L33/00;A61P1/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P3/14;A61P5/14;A61P7/04;A61P7/06;A61P9/00;A61P9/04;A61P9/10;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P19/08;A61P19/10;A61P21/04;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P35/02;A61P35/04;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D409/04;C07D409/14;C07D417/04;C07D417/14;C12N9/99;(IPC1-7):C07D409/02;C07D409/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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