Diagnosing and treating cancer cells using Sal2

摘要

The invention features the use of Sal2 nucleic acids and proteins in methods for treating patients having proliferative disorders, such as cancers, involving mutations in a Sal2 nucleic acid sequence and in the protein that it encodes. In addition, these treatment methods may also be used for patients having a mutation in a nucleic acid sequence encoding a protein that interacts with Sal2 or that functions in a signaling pathway involving Sal2. Furthermore, Sal2 may be used as an anti-viral agent that interferes with the ability of a DNA tumor virus to replicate and disseminate in a cell.