A process for producing Dosage Units of Medicines in Solid Form

摘要

1,178,059. Producing dosage units. APOTEKARSOCIETETEN. 23 Oct., 1967 [11 Nov., 1966], No. 48060/67. Heading B5A. Dosage units of medicines in solid form are made by mixing an active medical ingredient with a carrier which is solid at room temperature but liquid at higher temperatures and feeding the molten mixture 1 into the nip 41 of a pair of cooled rotating rollers 2 and 3, the rollers having corresponding cavities 4 of the correct size between which the dosage units are formed. The units may be subjected to a finishing treatment such as coating after leaving the cavity. The medicinal ingredient may be potassium chloride. The carrier preferably has a melting point above 37‹ C. and may be a fat, wax or a thermoplastics material. The medicinal ingredient is preferably incorporated into the carrier as a fine powder and may comprise up to 80% by weight of the units although 0À5-2% by wt. is preferred.