NOVEL TRICYCLIC HYDROXY CARBOXAMIDES AND DERIVATIVES THEREOFTOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS

摘要

This invention provides novel substituted tricyclic carboxamides which act a s oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesare an delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the centr al nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.