发明名称 |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
摘要 |
<p>The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to induce an immune response in a subject. The method includes administering to the subject a therapeutically effective amount of nucleic acid encoding an antigenic polypeptide, and a therapeutically effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide. The invention also provides a method for treating a subject having or at risk of having viral-mediated disorder, comprising administering to the subject a therapeutically effective amount of a nucleic acid encoding an antigenic polypeptide and an effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide</p> |
申请公布号 |
AU753688(B2) |
申请公布日期 |
2002.10.24 |
申请号 |
AU19980067595 |
申请日期 |
1998.03.10 |
申请人 |
OTTAWA CIVIC LOEB RESEARCH INSTITUTE;QIAGEN GMBH;THE UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
HEATHER L. DAVIS;JOACHIM SCHORR;ARTHUR M. KRIEG;DENNIS KLINMAN;ALFRED D. STEINBERG |
分类号 |
A61K47/02;A61K39/29;A61K39/39;A61K48/00;A61P31/04;A61P31/12;A61P33/00;(IPC1-7):A61K39/39 |
主分类号 |
A61K47/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|