发明名称 |
Method for producing 3-l-menthoxypropane-1,2-diol |
摘要 |
A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.
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申请公布号 |
US2002156327(A1) |
申请公布日期 |
2002.10.24 |
申请号 |
US20020115096 |
申请日期 |
2002.04.04 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
AMANO AKIRA;AKIYAMA TERUYOSHI;MIURA TAKASHI;HAGIWARA TOSHIMITSU |
分类号 |
C07C41/09;C07B53/00;C07B61/00;C07C41/03;C07C41/26;C07C43/196;C07C67/10;C07C69/003;C07C69/10;C07C69/18;(IPC1-7):C07C41/03 |
主分类号 |
C07C41/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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