TRICYCLIC DIAZEPINES AS TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS

摘要

This invention provides novel tricyclic diazepine compounds as well as metho ds and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist acivity, including treatment of preterm labor, dysmerorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; an d may be useful in the prevention and treatment of disfunctions of the oxytoci n system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.