Replication competent hepatitis C virus and methods of use

摘要

The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide present in the 3' non-translated RNA. The invention also includes methods for modifying a hepatitis C virus, selecting a replication competent hepatitis C virus, detecting a replication competent hepatitis C virus, and identifying a compound that inhibits replication of a hepatitis C virus.