| 摘要 |
A compound of the formulae (I) or (II): wherein Y is a moiety selected from NR or -(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; (Z), represents; (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C 1- C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, -CONH2, -CONH[(C1-C6)lower alkyl], -CON[(C1- C6)lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ri ng having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; (W), represents: (1) a phenyl ring optional ly substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy , (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, -CONH2, - CONH[(C1-C6)lower alkyl], -CON[(C1-C6)lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionall y substituted by (C1-C6) lower alkyl, (C1-C6) lower alkoxy, or halogen; or (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom , optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy, (X), represents a 5-membered aromatic (unsaturated) heterocyclic rin g having one sulfur atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy; R1 is a moiety of Formula (0 or N), and R2 , R3, R7, R8 and R9 are, independently, selected from a group consis ting of hydrogen, (C1-C3) lower alkyl, OCH3 halogen, CF3, -SCH3, OCF3, SCF3, or CN; or a pharmaceutically acceptable salt, or pro-drug form thereof.
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