发明名称 |
PROCESS FOR PREPARING QUINOLYLACRYLONITRILE AND INTERMEDIATES THEREFOR |
摘要 |
3-Ä2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜprop-2-enenitrite is prepared by reacting 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylÜ-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜ-prop-2-enenitrite is directly formed. |
申请公布号 |
EP1251123(A1) |
申请公布日期 |
2002.10.23 |
申请号 |
EP20010901537 |
申请日期 |
2001.01.24 |
申请人 |
UBE INDUSTRIES, LTD.;NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
HARADA, KATSUMASA;NISHINO, SHIGEYOSHI;OKADA, NAOKO;SHIMA, HIDETAKA;HARADA, TAKASHI |
分类号 |
C07D215/12;C07D215/14;(IPC1-7):C07D215/12 |
主分类号 |
C07D215/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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