| 摘要 |
PROBLEM TO BE SOLVED: To provide a new thienopyrimidine derivative or its salt possessing a metabotropic glutamate receptor activity which is useful as a pharmaceutical. SOLUTION: The thienopyrimidine derivative or its salt is represented by formula (I) (wherein R<1> is H, a halogen, OH, SH, a lower alkyl, a halogeno lower alkyl, a cycloalkyl or an optionally substituted amino; R<2> is -N(R<2a> )R<2b> , -O-R<2a> , -S-R<2a> , -N(R<2c> )-C(O)-R<2a> or -C(O)-N(R<2a> )R<2b> ; R<3> is a lower alkyl optionally substituted with H or OH or a nitrogen-containing heterocyclic ring-lower alkyl-; and R<4> is H, acyl, a halogen, nitro, a lower alkyl, -(Alk1)p-X-(Alk2)q-Y-R<5> , -CH=R<5a> or -C(O)-O-R<5b> ). A pharmaceutical comprises this as an active component.
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