<p>The present invention provides substantially purified fragments of a Delta protein as well as derivatives and analogs thereof, characterized by the ability in vitro, when expressed on the surface of a first cell to bind to a Notch protein, or a second Delta protein or fragment expressed on the surface of a second cell, the nucleic acid sequences encoding said fragments as well as vectors and recombinant cells containing the same. A method of producing a fragment of a Delta protein is also disclosed. <IMAGE></p>
申请公布号
EP0576623(B1)
申请公布日期
2002.10.23
申请号
EP19920911557
申请日期
1992.05.01
申请人
YALE UNIVERSITY;ADVANCED RESEARCH & TECHNOLOGY INSTITUTE