METHOD FOR PURIFYING OPTICALLY ACTIVE 1-(FLUOROPHENYL) ETHYLAMINE

摘要

PROBLEM TO BE SOLVED: To provide a method for purifying optically active 1-(fluorophenyl) ethylamines of formula 1 (wherein n is 1-5 and a fluorine atom or fluorine atoms may be in any substituting position except the case where n is 1 and the fluorine atom is in the ortho-position; R is an optically activeα-arylethyl group of C*HMeAr; Ar is a phenyl group or a 1- or 2-naphthyl group; and *is an asymmetric carbon) which are important intermediates of pharmaceuticals and agricultural chemicals with good industrial efficiency in high optical purity. SOLUTION: The optically active 1-(fluorophenyl)ethylamines of formula 1 are converted to the salts of an inorganic acid or an organic acid, and then purified by recrystallization.