发明名称 Process for the preparation of crystalline and solvent free iohexol
摘要 The object of the present invention is an industrial process for the purification and removal of residual solvents from iohexol, based on the suspension of crystalline iohexol, eventually containing residual solvents above 100 ppm, in a fluid wherein it has a low solubility, followed by heating, filtration and drying. The process allows the formation of crystalline iohexol with no residual organic residual solvent above 100 ppm and with an increased purity level.
申请公布号 US6469208(B1) 申请公布日期 2002.10.22
申请号 US19970964339 申请日期 1997.11.04
申请人 HOVIONE INTER LTD. 发明人 VILLAX GUIDO DU BOULAY;DE CARVALHO ALEXANDRE JOSE GANCHAS;PEREZ CARLOS MANUEL ALVAREZ
分类号 A61K49/04;C07B63/00;C07C231/24;C07C237/46;(IPC1-7):C07C233/22 主分类号 A61K49/04
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