发明名称 |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies |
摘要 |
The present invention relates to chimeric molecules comprising an oligonucleotide complementary to a region of the ribonucleotide component of telomerase attached to an activator of RNase L ("activator-antisense complex") which specifically cleaves the ribonucleotide portion of a telomerase enzyme. The present invention relates to methods of inhibiting telomerase enzymatic activity with activator-antisense complexes targeted to the RNA component of telomerase. The present invention further relates to methods of treating malignant neoplastic disease, wherein the malignant cells contain a telomerase activity that is necessary for the growth of the malignant cells.
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申请公布号 |
US6468983(B2) |
申请公布日期 |
2002.10.22 |
申请号 |
US19980018125 |
申请日期 |
1998.02.03 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SILVERMAN ROBERT H.;KONDO SEIJI;COWELL JOHN K.;LI GUIYING;TORRENCE PAUL F. |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K45/06;A61P35/00;A61P43/00;C07H21/00;C12N15/113;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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