CARRIER SYSTEM FOR SPECIFIC ARTERY WALL GENE DELIVERY
摘要
An artery wall binding peptide (AWBP) based on the artery wall cell-binding domain of apolipoprotein B-100 was conjugated to a cationic backbone configured for forming a complex with a nucleic acid to produce a composition that enhances gene transfer to artery wall cells. An illustrative cationic backbone is poly(ethylene glycol)-grafted-poly(L-lysine) (PEG-g-PLL). Methods of making and using the composition for gene transfer are also described.
申请公布号
WO0242426(A3)
申请公布日期
2002.10.17
申请号
WO2001US47072
申请日期
2001.11.09
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;YU, LEI;KIM, SUNG, WAN;NAH, JAE-WOON