发明名称 |
SOLID PHARMACEUTICAL COMPOSITION COMPRISING 4 -CYANO-TRIFLUORO-3-(4-FLUOROPHENYLSULPHONYL)-2-HYDROXY-2-METHYLPROPIONO- M TOLUIDIDE AND PVP |
摘要 |
The present invention relates to a pharmaceutical formulation comprising the drug 4'-cyano- alpha ', alpha ', alpha '-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide in a solid dispersion with PVP. In one embodiment, >50% of the drug is provided in the form of the R-enantiomer. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of PVP in solid dispersion with the drug (in one embodiment wherein >50% of the 4'-cyano- alpha ', alpha ', alpha '-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide is provided in the form of the R-enantiomer) for increasing the bioavailability of the drug; for reducing inter-patient variability in plasmaconcentrations of the drug; for enhancing the storage stability of the drug; or for treating and/or reducing the risk of prostate cancer in a patient.
|
申请公布号 |
WO02080902(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
WO2002GB01439 |
申请日期 |
2002.03.27 |
申请人 |
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;CAHILL, JULIE, KAY;BATEMAN, NICOLA, FRANCES |
发明人 |
CAHILL, JULIE, KAY;BATEMAN, NICOLA, FRANCES |
分类号 |
A61K9/10;A61K;A61K9/14;A61K31/277;A61K47/32;A61P35/00;(IPC1-7):A61K31/277 |
主分类号 |
A61K9/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|