发明名称 |
Methods and compositions for the treatment of psoriasis |
摘要 |
This invention provides methods of treating psoriasis which entail eliciting an immune response in an individual against an antigen aberrantly expressed in psoriatic tissue, such as a ganglioside, in an individual. The anti-ganglioside immune response is elicited by administration of an antigen such as a ganglioside, an anti-idiotype moiety for a ganglioside, or a polynucleotide encoding an anti-idiotype moiety. Also described is a strategy for developing additional compositions for psoriasis. The compositions elicit an immunological response against a target antigen present on psoriatic tissue, which in turn can be detected using antibody affinity-purified from the serum of the treated subject. The presence of the immunological response correlates positively with control or resolution of the psoriatic symptoms.
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申请公布号 |
US2002150572(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
US20010990205 |
申请日期 |
2001.11.20 |
申请人 |
FOON KENNETH A.;CHATTERJEE MALAYA |
发明人 |
FOON KENNETH A.;CHATTERJEE MALAYA |
分类号 |
G01N33/50;A61K39/00;A61K39/395;A61P17/06;C07K16/42;C12N15/13;G01N33/15;G01N33/564;G01N33/569;G01N33/68;(IPC1-7):A61K39/395;G01N33/53;C08B37/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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