发明名称 |
Piperidinylethyl-, phenoxyethyl-, and beta-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity |
摘要 |
The present invention is directed to derivatives of piperidinylethyl, phenoxyethyl, and fluorophenethyl bromopyridyl thioureas, which have been found to be effective non-nucleoside inhibitors (NNRTI) of NNI-resistant and multi-drug resistant human immunodeficiency virus (HIV)-1 reverse transcriptase (RT). The present invention is further directed to methods of using the above derivatives to treat patients with NNI-resistant or multi-drug resistant human immunodeficiency virus (HIV)-1.
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申请公布号 |
US2002151568(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
US20010006300 |
申请日期 |
2001.12.06 |
申请人 |
UCKUN FATIH M.;VENKATACHALAM TARACAD K. |
发明人 |
UCKUN FATIH M.;VENKATACHALAM TARACAD K. |
分类号 |
A61K31/44;A61K31/4545;C07D213/75;(IPC1-7):A61K31/454 |
主分类号 |
A61K31/44 |
代理机构 |
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地址 |
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