发明名称 |
PROCESS FOR COUPLING AMINO ACIDS TO AN ANTIFOLATE SCAFFOLD |
摘要 |
A synthetic process is disclosed for coupling amino acids to a substrate. The process involves dissolving the amino acid and the scaffold in a non-polar aprotic solvent, and agitating the resulting mixture for a predetermined time. The process is specially suited to the synthesis of antifolate compounds having useful applications in the medical fields of oncology, inflammatory diseases and others.
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申请公布号 |
WO02081455(A1) |
申请公布日期 |
2002.10.17 |
申请号 |
WO2002US08932 |
申请日期 |
2002.03.22 |
申请人 |
BIONUMERIK PHARMACEUTICALS, INC.;KOCHAT, HARRY;WU, YE |
发明人 |
KOCHAT, HARRY;WU, YE |
分类号 |
C07D475/04;(IPC1-7):C07D239/84;C07D487/04 |
主分类号 |
C07D475/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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