Carboxylic acid amides having antithrombotic activity

摘要

Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: Exemplary are: (1) (L)-2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-[3-methyl-4-(2-aminocarbonyl-pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide, (2) 2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-{3-methyl-4-[2-(tert.butoxycarbonyl-aminomethyl)-piperidin-1-yl-carbonyl]-phenyl}-acetamide, and (3) 2-(5-aminomethyl-2-hydroxy-phenyl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide.