| 摘要 |
The present invention relates to diazepine derivatives of formula (I) wherein R represents hydrogen or C>1-4< alkyl; R>1< represents hydrogen or C>1-4< alkyl; R>2< represents trifluoromethyl, C>1-4< alkyl, C>1-4< alkoxy, trifluoromethoxy or halogen; R>3< represents halogen or C>1-4< alkyl; R>4< represents hydrogen, halogen, C>1-4< alkyl or COR>6<; R>5< represents hydrogen, C>1-4< alkyl or R>5< together within the R>1< represents C>3-7< cycloalkyl; R>6< represents hydroxy, amino, methylamino, dimethylamino, 5 membered heteroaryl group containing 1 to 3 heteroatoms selected independently from oxygen, sulphur and nitrogen or a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms; m or n are independently zero or an integer from 1 to 3; X and Y are independently NR>7< or methylene; provided that when X is NR>7<, Y is methylene and when X is methylene, Y is NR>7<; R>7< represents hydrogen, C>1-4< alkyl or C>3-7< cycloalkyl;and pharmaceutically acceptable salts and solvates thereof;to process for their preparation and their use in the treatment of condition mediated by tachykinins.
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