| 摘要 |
A transdermal electrotransport drug delivery device (10) having an anode (22 ), a cathode (24) and a source of electrical power (32) electrically connected to the anode and the cathode. At least one of the anode and the catode includes an electrode (22, 24) and a reservoir (26, 28) comprised of a housing compos ed of a polymeric material and an aqueous medium in contact with the housing. T he aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amoun t sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materia ls used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
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